3D Hemodynamic Numerical Simulation of Carotid Artery Aneurysm Before and after Surgery Based on CT Date_Journal of Biomedical Engineering

Authors：

RENGuorong ¹ , CAOXiaoqiang ² , WANGDongqing ² ,  JIANGPing ³ , LIYusheng ¹ , PEIBing ¹

1. Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang 212013, China;
2. Department of Radiology, the Affiliated Hospital, Jiangsu University, Zhenjiang 212013, China;
3. Department of Anatomy, School Medicine Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China;

Corresponding?author：

JIANGPing, Email: jiangping1111@163.com

Keywords：

carotid artery aneurysm; hemodynamic; mimics; recurrence

DOI：

10.7507/1001-5515.20140064

Video：

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Hemodynamic situation is an important factor of recurrence of postoperative carotid artery aneurysm. In order to investigate the hemodynamic factors of postoperative carotid artery aneurysm affect carotid artery aneurysm recurrence, we established a 3D finite element carotid artery aneurysm for the preoperative and postoperative periods using the three-dimensional reconstruction techniques. And then we measured the hemodynamic factors of carotid artery aneurysm of preoperative and postoperative by the finite element method. The carotid artery aneurysm model has an accurate and realistic shape; the pressure of the recurrence of aneurysm was reduced significantly after surgery,wall shear stress increased significantly at residual neck, and blood flow velocity increased significantly, which will increase the risk of recurrence. The hemodynamic analysis provides a reference for development of aneurysm clinical treatment programs and prevention of recurrence.

Citation： RENGuorong, CAOXiaoqiang, WANGDongqing, JIANGPing, LIYusheng, PEIBing. 3D Hemodynamic Numerical Simulation of Carotid Artery Aneurysm Before and after Surgery Based on CT Date. Journal of Biomedical Engineering, 2014, 31(2): 341-346. doi: 10.7507/1001-5515.20140064 Copy

1.	于紅玉,李海云,張瑩,等.基于影像數據的三維顱內動脈瘤血流動力學數值:手術前后壁面切模擬對比[J].中國組織工程研究與臨床康復,2010,14(39):7327-7330.
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3.	CASTRO M A,PUTMAN C M,CEBRAL J R.Computational fluid dynamics modeling of intracranial aneurysms:effects of parent artery segmentation on intra-aneurysmal hemodynamics[J].AJNR Am J Neuroradiol,2006,27(8):1703-1709.
4.	穆士卿,楊新建,張瑩,等.顱內典型囊性動脈瘤的三維數值模擬及血液動力學分析[J].中國微侵襲神經外科雜志,2009,14(7):312-315.
5.	陳旭東,羅祺,羅毅男,等.頂端動脈瘤的血流動力學數值模擬切應力分析[J].吉林大學學報:醫學版,2005,31(3):381-383.
6.	顧兆勇,張宏斌,孟憲龍,等.支架植入顱內蜿蜒型動脈瘤的血液動力學仿真[J].醫用生物力學,2009,24(1):64-69.
7.	黃清海,張星,施洋,等.不同類型腦動脈瘤內流體力學的三維數值模擬研究[J].中華神經外科疾病研究雜志,2009,8(1):69-72.
8.	王偉華.基于CT的腦動脈瘤三維模型重建及有限元分析[D].北京:北京工業大學,2009.
9.	戴建華,丁光宏,龔劍秋,等.顱內動脈瘤的血液動力學二維數值模擬[J].復旦學報(自然科學版),2004,43(3):392-396.
10.	LADISA J F,TAYLOR C A,FEINSTEIN J A.Aortic coarctation:recent developments in experimental and computational methods to assess treatments for this simple condition[J].Prog Pediatr Cardiol,2010,30(1):45-49.
11.	張星.支架對腦動脈瘤血液動力學影響的三維數值模擬研究[D].上海:第二軍醫大學,2008:1-64.
12.	邱曉寧,費智敏,王煒哲,等.顱內動脈瘤夾閉手術的血流動力學數值分析[J].生物醫學工程學雜志,2012,29(1):102-106,111.
13.	HASSAN T,TIMOFEEV E V,SAITO T,et al.Computational replicas:anatomic reconstructions of cerebral vessels as volume numerical grids at three-dimensional angiography[J].AJNR Am J Neuroradiol,2004,25(8):1356-1365.
14.	SURDELL D L,HAGE Z,EDDLEMAN C S,et al.Revascularization for complex intracranial aneurysms[J].Neurosurg Focus,2008,24(2):16-21.
15.	LAWTON M T,HAMILTON M G,MORCOS J J,et al.Revascularization and aneurysm surgery:current techniques,indications,and outcome[J].Neurosurgery,1996,38(1):83-92;discussion:92.
16.	SEKHAR L N,NATARAJAN S K,ELLENBOGEN R G,et al.Cerebral revascularization for ischemia,aneurysms,and cranial base tumors[J].Neurosurgery,2008,62(6 Suppl 3):S1373-S1408.
17.	ALI M J,BENDOK B R,TELLA M N,et al.Arterial reconstruction by direct surgical clipping of a basilar artery dissecting aneurysm after failed vertebral artery occlusion:technical case report and literature review[J].Neurosurgery,2003,52(6):1475-1480.
18.	CANTóN G,LEVY D I,LASHERAS J C,et al.Flow changes caused by the sequential placement of stents across the neck of sidewall cerebral aneurysms[J].J Neurosurg,2005,103(5):891-902.
19.	張炘,段傳志,李鐵林,等.切應力在血流動力學因素影響顱內動脈瘤形成和破裂中的作用[J].介入放射學雜志,2011,20(4):319-324.
20.	何旭英,段傳志,李鐵林,等,頸內動脈-后交通動脈瘤形成的形態學因素分析[J].國際腦血管病雜志,2007,15(6):460-463.
21.	王芙昱.基于計算流體力學技術的個體化顱內動脈瘤的血流動力學模型與試驗[D].北京:中國人民解放軍軍醫進修學院,2008.
22.	劉磊,許百男,王芙昱,等.顱內動脈瘤血流動力學的計算流體動力學數值模擬研究[J].臨床神經外科雜志,2011,8(1):19-22.
23.	CHIEN A,CASTRO M A,TATESHIMA S,et al.Quantitative hemodynamic analysis of brain aneurysms at different locations[J].AJNR Am J Neuroradiol,2009,30(8):1507-1512.
24.	盧海濤,楊鵬飛,黃清海,等.顱內動脈瘤壁面壓力分布的數值模擬研究[J].中華腦血管病雜志:電子版,2009,3(5):225-232.
25.	DOLAN J M,MENG H,SINGH S,et al.High fluid shear stress and spatial shear stress gradients affect endothelial proliferation,survival,and alignment[J].Ann Biomed Eng,2011,39(6):1620-1631.
26.	MUT F,L?HNER R,CHIEN A,et al.Computational hemodynamics framework for the analysis of cerebral aneurysms[J].Int J Numer Method Biomed Eng,2011,27(6):822-839.

1. 于紅玉,李海云,張瑩,等.基于影像數據的三維顱內動脈瘤血流動力學數值:手術前后壁面切模擬對比[J].中國組織工程研究與臨床康復,2010,14(39):7327-7330.
2. POETHKE J,GOUBERGRITS L,KERTZSCHER U,et al.Impact of imaging modality for analysis of a cerebral aneurysm:comparison between CT,MRI and 3DRA[C]//IFMBE Proceedings,2009,22:1889-1893.
3. CASTRO M A,PUTMAN C M,CEBRAL J R.Computational fluid dynamics modeling of intracranial aneurysms:effects of parent artery segmentation on intra-aneurysmal hemodynamics[J].AJNR Am J Neuroradiol,2006,27(8):1703-1709.
4. 穆士卿,楊新建,張瑩,等.顱內典型囊性動脈瘤的三維數值模擬及血液動力學分析[J].中國微侵襲神經外科雜志,2009,14(7):312-315.
5. 陳旭東,羅祺,羅毅男,等.頂端動脈瘤的血流動力學數值模擬切應力分析[J].吉林大學學報:醫學版,2005,31(3):381-383.
6. 顧兆勇,張宏斌,孟憲龍,等.支架植入顱內蜿蜒型動脈瘤的血液動力學仿真[J].醫用生物力學,2009,24(1):64-69.
7. 黃清海,張星,施洋,等.不同類型腦動脈瘤內流體力學的三維數值模擬研究[J].中華神經外科疾病研究雜志,2009,8(1):69-72.
8. 王偉華.基于CT的腦動脈瘤三維模型重建及有限元分析[D].北京:北京工業大學,2009.
9. 戴建華,丁光宏,龔劍秋,等.顱內動脈瘤的血液動力學二維數值模擬[J].復旦學報(自然科學版),2004,43(3):392-396.
10. LADISA J F,TAYLOR C A,FEINSTEIN J A.Aortic coarctation:recent developments in experimental and computational methods to assess treatments for this simple condition[J].Prog Pediatr Cardiol,2010,30(1):45-49.
11. 張星.支架對腦動脈瘤血液動力學影響的三維數值模擬研究[D].上海:第二軍醫大學,2008:1-64.
12. 邱曉寧,費智敏,王煒哲,等.顱內動脈瘤夾閉手術的血流動力學數值分析[J].生物醫學工程學雜志,2012,29(1):102-106,111.
13. HASSAN T,TIMOFEEV E V,SAITO T,et al.Computational replicas:anatomic reconstructions of cerebral vessels as volume numerical grids at three-dimensional angiography[J].AJNR Am J Neuroradiol,2004,25(8):1356-1365.
14. SURDELL D L,HAGE Z,EDDLEMAN C S,et al.Revascularization for complex intracranial aneurysms[J].Neurosurg Focus,2008,24(2):16-21.
15. LAWTON M T,HAMILTON M G,MORCOS J J,et al.Revascularization and aneurysm surgery:current techniques,indications,and outcome[J].Neurosurgery,1996,38(1):83-92;discussion:92.
16. SEKHAR L N,NATARAJAN S K,ELLENBOGEN R G,et al.Cerebral revascularization for ischemia,aneurysms,and cranial base tumors[J].Neurosurgery,2008,62(6 Suppl 3):S1373-S1408.
17. ALI M J,BENDOK B R,TELLA M N,et al.Arterial reconstruction by direct surgical clipping of a basilar artery dissecting aneurysm after failed vertebral artery occlusion:technical case report and literature review[J].Neurosurgery,2003,52(6):1475-1480.
18. CANTóN G,LEVY D I,LASHERAS J C,et al.Flow changes caused by the sequential placement of stents across the neck of sidewall cerebral aneurysms[J].J Neurosurg,2005,103(5):891-902.
19. 張炘,段傳志,李鐵林,等.切應力在血流動力學因素影響顱內動脈瘤形成和破裂中的作用[J].介入放射學雜志,2011,20(4):319-324.
20. 何旭英,段傳志,李鐵林,等,頸內動脈-后交通動脈瘤形成的形態學因素分析[J].國際腦血管病雜志,2007,15(6):460-463.
21. 王芙昱.基于計算流體力學技術的個體化顱內動脈瘤的血流動力學模型與試驗[D].北京:中國人民解放軍軍醫進修學院,2008.
22. 劉磊,許百男,王芙昱,等.顱內動脈瘤血流動力學的計算流體動力學數值模擬研究[J].臨床神經外科雜志,2011,8(1):19-22.
23. CHIEN A,CASTRO M A,TATESHIMA S,et al.Quantitative hemodynamic analysis of brain aneurysms at different locations[J].AJNR Am J Neuroradiol,2009,30(8):1507-1512.
24. 盧海濤,楊鵬飛,黃清海,等.顱內動脈瘤壁面壓力分布的數值模擬研究[J].中華腦血管病雜志:電子版,2009,3(5):225-232.
25. DOLAN J M,MENG H,SINGH S,et al.High fluid shear stress and spatial shear stress gradients affect endothelial proliferation,survival,and alignment[J].Ann Biomed Eng,2011,39(6):1620-1631.
26. MUT F,L?HNER R,CHIEN A,et al.Computational hemodynamics framework for the analysis of cerebral aneurysms[J].Int J Numer Method Biomed Eng,2011,27(6):822-839.

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3D Hemodynamic Numerical Simulation of Carotid Artery Aneurysm Before and after Surgery Based on CT Date

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