以Vogt-Koyanagi-Harada綜合征為首要表現的急性髓系白血病1例_Chinese Journal of Ocular Fundus Diseases

Authors：

童桂芳 , 梅鋒 ,  吳曉蓉

南昌大學第一附屬醫院眼科, 南昌 330006;

Corresponding?author：

吳曉蓉, Email: wxr98021@126.com

Keywords：

Vogt-Koyanagi-Harada 綜合征; 視網膜脫離; 白血病; 病例報告

DOI：

10.3760/cma.j.cn511434-20250416-00175

Video：

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Citation： 童桂芳, 梅鋒, 吳曉蓉. 以Vogt-Koyanagi-Harada綜合征為首要表現的急性髓系白血病1例. Chinese Journal of Ocular Fundus Diseases, 2026, 42(1): 56-58. doi: 10.3760/cma.j.cn511434-20250416-00175 Copy

1.	Wachter F, Pikman Y. Pathophysiology of acute myeloid leukemia[J]. Acta Haematol, 2024, 14(2): 229-246. DOI: 10.1159/000536152.
2.	Reddy SC, Jackson N, Menon BS. Ocular involvement in leukemia—a study of 288 cases[J]. Ophthalmologica, 2003, 217(6): 441-445. DOI: 10.1159/000073077.
3.	Chandra A, Chakraborty U, Ganai S, et al. Roth spots in acute myeloid leukaemia[J/OL]. BMJ Case Rep, 2020, 13(9): e238133[2020-09-02]. https://pubmed.ncbi.nlm.nih.gov/32878844/. DOI: 10.1136/bcr-2020-238133.
4.	Hafeez MU, Ali MH, Najib N, et al. Ophthalmic manifestations of acute leukemia[J/OL]. Cureus, 2019, 11(1): e3837[2019-01-07]. https://pubmed.ncbi.nlm.nih.gov/30891378/. DOI: 10.7759/cureus.3837.
5.	Adaniya A, Bazterrechea P, Trucco JI, et al. Bilateral macular detachment: choroid as a sanctuary of acute lymphoblastic leukemia[J/OL]. Am J Ophthalmol Case Rep, 2020, 19: 100746[2020-05-13]. https://pubmed.ncbi.nlm.nih.gov/32478200/. DOI: 10.1016/j.ajoc.2020.100746.
6.	Hassanpoor N, Niyousha MR. Acute lymphoblastic leukemia presenting as acute Vogt-Koyanagi-Harada syndrome[J]. Case Rep Ophthalmol, 2020, 11(2): 481-485. DOI: 10.1159/000509341.
7.	Vieira L, Silva NA, Medeiros MD, et al. Acute lymphoblastic leukemia presenting with bilateral serous macular detachment[J]. Arq Bras Oftalmol, 2015, 78(6): 382-384. DOI: 10.5935/0004-2749.20150101.
8.	Sayadi J, Gouider D, Allouche Y, et al. Ophthalmic manifestations of newly diagnosed acute leukemia patients in a Tunisian cohort[J]. Clin Ophthalmol, 2022, 16: 3425-3435. DOI: 10.2147/OPTH.S365648.
9.	Laimon DN, Sakr DH, Atef B, et al. Highlights of ophthalmological manifestations in newly diagnosed acute leukemia: a correlation with hematological parameters[J]. Ann Hematol, 2024, 103(9): 3519-3533. DOI: 10.1007/s00277-024-05861-2.
10.	Khurana M, Singh A, Pal H, et al. Ocular involvement—an unusual initial presentation of chronic myeloid leukemia: acase report[J]. J Family Med Prim Care, 2023, 12(7): 1460-1463. DOI: 10.4103/jfmpc.jfmpc_2370_22.
11.	Read RW, Holland GN, Rao NA, et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature[J]. Am J Ophthalmol, 2001, 131(5): 647-652. DOI: 10.1016/s0002-9394(01)00925-4.
12.	Merle H, Hage R, Meniane JC, et al. Retinal manifestations in adult T-cell leukemia/lymphoma related to infection by the human T-cell lymphotropic virus type-1[J]. Retina, 2016, 36(7): 1364-1371. DOI: 10.1097/IAE.0000000000000927.
13.	Zimmerman L, Thoreson H. Sudden loss of vision in acute leukemia: a clinicopathologic report of two unusual cases[J]. Surv Ophthalmol, 1964, 146: 467-473.
14.	Yan W, Wang Y, Zheng X, et al. Acute lymphocytic leukemia with initial manifestation of serous retinal detachment and choroidal thickening: case report and literature review[J/OL]. J Int Med Res, 2021, 49(3): 300060520964373[2021-03-01]. https://pubmed.ncbi.nlm.nih.gov/33765851/. DOI: 10.1177/0300060520964373.
15.	Naseripour M, Abdolalizadeh P, Abdi F, et al . Serous retinal detachment as an initial presentation of childhood acute myeloid leukemia[J/OL]. Can J Ophthalmol, 2019, 54(4): e170-e173[2018-11-23]. https://pubmed.ncbi.nlm.nih.gov/31358158/. DOI: 10.1016/j.jcjo.2018.10.008.
16.	Spaide RF, Goldbaum M, Wong DW, et al. Serous detachment of the retina[J]. Retina, 2003, 23(6): 820-846. DOI: 10.1097/00006982-200312000-00013.

1. Wachter F, Pikman Y. Pathophysiology of acute myeloid leukemia[J]. Acta Haematol, 2024, 14(2): 229-246. DOI: 10.1159/000536152.
2. Reddy SC, Jackson N, Menon BS. Ocular involvement in leukemia—a study of 288 cases[J]. Ophthalmologica, 2003, 217(6): 441-445. DOI: 10.1159/000073077.
3. Chandra A, Chakraborty U, Ganai S, et al. Roth spots in acute myeloid leukaemia[J/OL]. BMJ Case Rep, 2020, 13(9): e238133[2020-09-02]. https://pubmed.ncbi.nlm.nih.gov/32878844/. DOI: 10.1136/bcr-2020-238133.
4. Hafeez MU, Ali MH, Najib N, et al. Ophthalmic manifestations of acute leukemia[J/OL]. Cureus, 2019, 11(1): e3837[2019-01-07]. https://pubmed.ncbi.nlm.nih.gov/30891378/. DOI: 10.7759/cureus.3837.
5. Adaniya A, Bazterrechea P, Trucco JI, et al. Bilateral macular detachment: choroid as a sanctuary of acute lymphoblastic leukemia[J/OL]. Am J Ophthalmol Case Rep, 2020, 19: 100746[2020-05-13]. https://pubmed.ncbi.nlm.nih.gov/32478200/. DOI: 10.1016/j.ajoc.2020.100746.
6. Hassanpoor N, Niyousha MR. Acute lymphoblastic leukemia presenting as acute Vogt-Koyanagi-Harada syndrome[J]. Case Rep Ophthalmol, 2020, 11(2): 481-485. DOI: 10.1159/000509341.
7. Vieira L, Silva NA, Medeiros MD, et al. Acute lymphoblastic leukemia presenting with bilateral serous macular detachment[J]. Arq Bras Oftalmol, 2015, 78(6): 382-384. DOI: 10.5935/0004-2749.20150101.
8. Sayadi J, Gouider D, Allouche Y, et al. Ophthalmic manifestations of newly diagnosed acute leukemia patients in a Tunisian cohort[J]. Clin Ophthalmol, 2022, 16: 3425-3435. DOI: 10.2147/OPTH.S365648.
9. Laimon DN, Sakr DH, Atef B, et al. Highlights of ophthalmological manifestations in newly diagnosed acute leukemia: a correlation with hematological parameters[J]. Ann Hematol, 2024, 103(9): 3519-3533. DOI: 10.1007/s00277-024-05861-2.
10. Khurana M, Singh A, Pal H, et al. Ocular involvement—an unusual initial presentation of chronic myeloid leukemia: acase report[J]. J Family Med Prim Care, 2023, 12(7): 1460-1463. DOI: 10.4103/jfmpc.jfmpc_2370_22.
11. Read RW, Holland GN, Rao NA, et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature[J]. Am J Ophthalmol, 2001, 131(5): 647-652. DOI: 10.1016/s0002-9394(01)00925-4.
12. Merle H, Hage R, Meniane JC, et al. Retinal manifestations in adult T-cell leukemia/lymphoma related to infection by the human T-cell lymphotropic virus type-1[J]. Retina, 2016, 36(7): 1364-1371. DOI: 10.1097/IAE.0000000000000927.
13. Zimmerman L, Thoreson H. Sudden loss of vision in acute leukemia: a clinicopathologic report of two unusual cases[J]. Surv Ophthalmol, 1964, 146: 467-473.
14. Yan W, Wang Y, Zheng X, et al. Acute lymphocytic leukemia with initial manifestation of serous retinal detachment and choroidal thickening: case report and literature review[J/OL]. J Int Med Res, 2021, 49(3): 300060520964373[2021-03-01]. https://pubmed.ncbi.nlm.nih.gov/33765851/. DOI: 10.1177/0300060520964373.
15. Naseripour M, Abdolalizadeh P, Abdi F, et al . Serous retinal detachment as an initial presentation of childhood acute myeloid leukemia[J/OL]. Can J Ophthalmol, 2019, 54(4): e170-e173[2018-11-23]. https://pubmed.ncbi.nlm.nih.gov/31358158/. DOI: 10.1016/j.jcjo.2018.10.008.
16. Spaide RF, Goldbaum M, Wong DW, et al. Serous detachment of the retina[J]. Retina, 2003, 23(6): 820-846. DOI: 10.1097/00006982-200312000-00013.

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以Vogt-Koyanagi-Harada綜合征為首要表現的急性髓系白血病1例

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