Study on correlation of retinal blood vessel density with blood pressure and retinal thickness in the macular region of glaucoma_Chinese Journal of Ocular Fundus Diseases

Authors：

 Lin Na ¹ , Deng Weidong ¹ , Li Bo ¹ , Wang Yange ²

1. Department of Ophthalmology, Luoyang First People's Hospital, Luoyang 471000, China;
2. Henan Provincial Eye Hospital, Zhengzhou 450000, China;

Corresponding?author：

Lin Na, Email: 298116192@qq.com

Keywords：

Glaucoma; Macular area; Retinal blood vessel density; Blood pressure; Retinal thickness; Correlation analysis

DOI：

10.3760/cma.j.cn511434-20230707-00302

Video：

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Objective To investigate the correlation of retinal blood vessel density with blood pressure and retinal thickness in the macular region of glaucoma. Methods A retrospective study. From March 2019 to March 2022, 100 glaucoma patients of 100 eyes (glaucoma group) and 100 healthy people of 100 eyes (control group) diagnosed in Department of Ophthalmology of Luoyang First People's Hospital were included in the study. The patients in the glaucoma group were subdivided into the early, intermediate, and late groups based on the average visual field defect value, which were 38, 32, and 30 cases, respectively. Optical coherence tomography angiography was used to scan the macular area of the examined eyes in a 3 mm×3 mm area. The software automatically divided the retina within 3 mm of the macular central concavity into 2 concentric circles centered on the macular central concavity, which were the central concave area with a diameter of 1 mm and the paracentral concave area with a diameter of 1-3 mm. The blood flow density and retinal thickness of the superficial retinal capillary plexus in the nasal, temporal, inferior, and superior quadrants of the retina within 3 mm of the macula were measured. Blood pressure was measured at the brachial artery using an electronic sphygmomanometer. Comparisons between two groups were made by independent samples t test, and comparisons between multiple groups were made by one-way analysis of variance. Correlations between retinal blood flow density and blood pressure and retinal thickness were analyzed by Spearman's correlation analysis. Results The retinal blood vessel density in the central fovea, parafoveal, inferior, and superior macular areas in the glaucoma group were lower than that in the control group, and with the aggravation of the disease, the retinal blood vessel density in the central fovea, parafoveal, inferior and superior macular areas gradually decreased; the retinal thicknesses in the foveal, parafoveal, inferior, and superior macular areas in the glaucoma group were lower than those in the control group, and with the aggravation of the disease, the retinal thicknesses in the foveal, parafoveal, inferior, and superior macular areas gradually decreased, the differences were statistically significant (P＜0.05). Systolic and diastolic blood pressure were higher in the glaucoma group than in the control group, and they increased gradually as the disease worsened (P＜0.05). Spearman's correlation analyses showed that in glaucoma patients, the density of retinal blood vessels in the macular central plexus, paracentral plexus, and inferior and superior retinas was positively correlated with retinal thickness in the corresponding areas and negatively correlated with blood pressure (P＜0.05). Conclusion The density of retinal blood vessels in the macular central plexus, paracentral plexus, and inferior and superior retinas are positively correlated with retinal thickness in the corresponding areas and negatively correlated with blood pressure.

Citation： Lin Na, Deng Weidong, Li Bo, Wang Yange. Study on correlation of retinal blood vessel density with blood pressure and retinal thickness in the macular region of glaucoma. Chinese Journal of Ocular Fundus Diseases, 2024, 40(3): 202-207. doi: 10.3760/cma.j.cn511434-20230707-00302 Copy

1.	張妍, 賈超, 張方順, 等. 原發性閉角型青光眼患者超聲乳化手術治療的臨床效果及對患者預后的影響[J]. 中國現代藥物應用, 2022, 16(5): 58-60. DOI: 10.14164/j.cnki.cn11-5581/r.2022.05.020.Zhang Y, Jia C, Zhang FS, et al. Clinical effect of clear lens phacoemulsification for primary angle- closure glaucoma and its influence on prognosis of patients[J]. Chin J Mod Drug Appl, 2022, 16(5): 58-60. DOI: 10.14164/j.cnki.cn11-5581/r.2022.05.020.
2.	Penteado RC, Zangwill LM, Daga FB, et al. Optical coherence tomography angiography macular vascular density measurements and the central 10-2 visual field in glaucoma[J]. J Glaucoma, 2018, 27(6): 481-489. DOI: 10.1097/IJG.0000000000000964.
3.	Yousefi S, Sakai H, Murata H, et al. Asymmetric patterns of visual field defect in primary open-angle and primary angle-closure glaucoma[J]. Invest Ophthalmol Vis Sci, 2018, 59(3): 1279-1287. DOI: 10.1167/iovs.17-22980.
4.	陳聰, 張祎草, 常新奇, 等. 經睫狀體扁平部玻璃體腔穿刺抽液聯合前房重建術治療惡性青光眼的療效觀察[J]. 臨床醫學, 2022, 42(3): 51-52. DOI: 10.19528/j.issn.1003-3548.2022.03.019.Chen C, Zhang YC, Chang XQ, et al. The efficacy of transciliary flattening vitreous cavity aspiration combined with anterior chamber reconstruction in the treatment of malignant glaucoma[J]. Clin Med, 2022, 42(3): 51-52. DOI: 10.19528/j.issn.1003-3548.2022.03.019.
5.	余學清, 魏偉, 張旭. 原發性閉角型青光眼黃斑區視網膜血管密度的相關性研究[J]. 江西醫藥, 2020, 55(6): 631-635. DOI: 10.3969/j.issn.1006-2238.2020.06.001.Yu XQ, Wei W, Zhang X. Relationship of retinal blood vessel density in macular region of primary angle-closure glaucoma[J]. Jiangxi Med J, 2020, 55(6): 631-635. DOI: 10.3969/j.issn.1006-2238.2020.06.001.
6.	中華醫學會眼科學分會青光眼學組, 中國醫師協會眼科醫師分會青光眼學組. 中國青光眼指南(2020年)[J]. 中華眼科雜志, 2020, 56(8): 573-586. DOI: 10.3760/cma.j.cn112142-20200313-00182.Glaucoma Group of Ophthalmology Branch of Chinese Medical Association, Glaucoma Group of Ophthalmologist Branch of Chinese Medical Doctor Association. Guidelines for glaucoma in China (2020)[J]. Chin J Ophthalmol, 2020, 56(8): 573-586. DOI: 10.3760/cma.j.cn112142-20200313-00182.
7.	趙燦. 青光眼視野缺損分級方法[J]. 中華實驗眼科雜志, 2013, 31(3): 292-297. DOI: 10.3760/cma.j.issn.2095-0160.2013.03.020.Zhao C. Staging visual field damage in glaucoma[J]. Chin J Exp Ophthalmol, 2013, 31(3): 292-297. DOI: 10.3760/cma.j.issn.2095-0160.2013.03.020.
8.	Rao HL, Dasari S, Riyazuddin M, et al. Diagnostic ability and structure-function relationship of peripapillary optical microangiography measurements in glaucoma[J]. J laucoma, 2018, 27(3): 219-226. DOI: 10.1097/IJG.0000000000000873.
9.	Cao D, Yang D, Huang Z, et al. Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy[J]. Acta Diabetol, 2018, 55(5): 469-477. DOI: 10.1007/s00592-018-1115-1.
10.	胡依博, 沈策英, 張培. 光學相干斷層掃描儀檢測視網膜神經纖維層厚度在慢性原發性閉角型青光眼早期診斷中應用[J]. 山西醫藥雜志, 2021, 50(10): 1630-1632. DOI: 10.3969/j.issn.0253-9926.2021.10.014.Hu YB, Shen CY, Zhang P. Application of optical coherence tomography to detect retinal nerve fiber layer thickness in early diagnosis of chronic primary angle-closure glaucoma[J]. Shanxi Med J, 2021, 50(10): 1630-1632. DOI: 10.3969/j.issn.0253-9926.2021.10.014.
11.	王偉, 王孌, 郭瑩. 定量分析原發性急性閉角型青光眼首次發作后視盤周圍毛細血管密度參數變化[J]. 河北醫藥, 2021, 43(17): 2610-2613. DOI: 10.3969/j.issn.1002-7386.2021.17.011.Wang W, Wang L, Guo Y. Quantitative analysis of the changes of capillary density parameters around the optic disc after the first attack of primary acute angle-closure glaucoma[J]. Hebei Med J, 2021, 43(17): 2610-2613. DOI: 10.3969/j.issn.1002-7386.2021.17.011.
12.	李紅月, 惠瑜, 孫海霞, 等. 原發性開角型及慢性閉角型青光眼患者視盤毛細血管密度和視野缺損的關聯性研究[J]. 中國眼耳鼻喉科雜志, 2019, 19(6): 400-404. DOI: 10.14166/j.issn.1671-2420.2019.06.010.Li HY, Hui Y, Sun HX, et al. The relationship between optic disc capillary density and mean defect of visual field open-angle and angle-closure glaucoma[J]. Chin J Ophthalmol and Otorhinolaryngol, 2019, 19(6): 400-404. DOI: 10.14166/j.issn.1671-2420.2019.06.010.
13.	Jo YH, Sung KR, Yun SC. The relationship between peripapillary vascular density and visual field sensitivity in primary open-angle and angle-closure glaucoma[J]. Invest Ophthalmol Vis Sci, 2018, 59(15): 5862-5867. DOI: 10.1167/iovs.18-25423.
14.	葉雪萍, 陳小舒, 周瑞芳. 農村地區中老年青光眼患者自我管理的現狀及其影響因素分析[J]. 廣西醫學, 2021, 43(23): 2886-2890. DOI: 10.11675/j.issn.0253-4304.2021.23.25.Ye XP, Chen XS, Zhou RF. Current situation of self-management of middle-aged and elderly glaucoma patients in rural areas and analysis of their influencing factors[J]. Guangxi Med J, 2021, 43(23): 2886-2890. DOI: 10.11675/j.issn.0253-4304.2021.23.25.
15.	Bae HW, Lee N, Lee HS, et al. Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies[J/OL]. PLoS One, 2014, 9(9): e108226[2014-09-25]. https://pubmed.ncbi.nlm.nih.gov/25254373/. DOI: 10.1371/journal.pone.0108226.
16.	江方方, 邢懿, 姜波, 等. 老年女性原發性開角型青光眼的影響因素分析[J]. 實用老年醫學, 2020, 34(10): 4. DOI: 10.3969/j.issn.1003-9198.2020.10.013.Jiang FF, Xing Y, Jiang B, et al. Analysis of the influencing factors of primary open-angle glaucoma in elderly women[J]. Prac Geriat, 2020, 34(10): 4. DOI: 10.3969/j.issn.1003-9198.2020.10.013.
17.	崔淑婷, 劉成生, 劉宏. 晶體植入聯合前段玻璃體切除術對惡性青光眼患者的臨床療效及其預后影響因素分析[J]. 醫學臨床研究, 2019, 36(3): 474-476. DOI: 10.3969/j.issn.1671-7171.2019.03.020.Cui ST, Liu CS, Liu H. Clinical efficacy and prognostic factors of lens implantation combined with anterior vitrectomy for malignant glaucoma[J]. J Clin Res, 2019, 36(3): 474-476. DOI: 10.3969/j.issn.1671-7171.2019.03.020.
18.	王曉蕾, 孫興懷. 視野半側缺損的原發性開角型青光眼視網膜微循環改變的研究[J]. 中華眼科雜志, 2021, 57(3): 201-206. DOI: 10.3760/cma.j.cn112142-20201102-00734.Wang XL, Sun XH. Retinal vessel density in primary open-angle glaucoma with a hemifield defect[J]. Chin J Ophthalmol, 2021, 57(3): 201-206. DOI: 10.3760/cma.j.cn112142-20201102-00734.
19.	陳小玲, 焦亞, 賀文山, 等. 光相干斷層掃描血管成像對開角型青光眼患者視網膜血管密度和視網膜厚度的測量[J]. 中華實驗眼科雜志, 2020, 38(5): 396-401. DOI: 10.3760/cma.j.cn115989-20200326-00208.Chen XL, Jiao Y, He WS, et al. Retinal vessel density and retinal thickness as measured using optical coherence tomography angiography in open angle glaucoma[J]. Chin J Exp Ophthalmol, 2020, 38(5): 396-401. DOI: 10.3760/cma.j.cn115989-20200326-00208.
20.	盧尹悅, 黃清清, 繆曉翠. 原發性急性閉角型青光眼急性發作期視網膜血管密度特征分析[J]. 創傷與急診電子雜志, 2023, 11(1): 23-27. DOI: 10.16746/j.cnki.11-9332/r.2023.01.004.Lu YY, Huang QQ, Miao XC. Characteristics of retinal vascular density in acute primary angle-closure glaucomaduring attack phase[J]. J Trauma Emerg, 2023, 11(1): 23-27. DOI: 10.16746/j.cnki.11-9332/r.2023.01.004.

1. 張妍, 賈超, 張方順, 等. 原發性閉角型青光眼患者超聲乳化手術治療的臨床效果及對患者預后的影響[J]. 中國現代藥物應用, 2022, 16(5): 58-60. DOI: 10.14164/j.cnki.cn11-5581/r.2022.05.020.Zhang Y, Jia C, Zhang FS, et al. Clinical effect of clear lens phacoemulsification for primary angle- closure glaucoma and its influence on prognosis of patients[J]. Chin J Mod Drug Appl, 2022, 16(5): 58-60. DOI: 10.14164/j.cnki.cn11-5581/r.2022.05.020.
2. Penteado RC, Zangwill LM, Daga FB, et al. Optical coherence tomography angiography macular vascular density measurements and the central 10-2 visual field in glaucoma[J]. J Glaucoma, 2018, 27(6): 481-489. DOI: 10.1097/IJG.0000000000000964.
3. Yousefi S, Sakai H, Murata H, et al. Asymmetric patterns of visual field defect in primary open-angle and primary angle-closure glaucoma[J]. Invest Ophthalmol Vis Sci, 2018, 59(3): 1279-1287. DOI: 10.1167/iovs.17-22980.
4. 陳聰, 張祎草, 常新奇, 等. 經睫狀體扁平部玻璃體腔穿刺抽液聯合前房重建術治療惡性青光眼的療效觀察[J]. 臨床醫學, 2022, 42(3): 51-52. DOI: 10.19528/j.issn.1003-3548.2022.03.019.Chen C, Zhang YC, Chang XQ, et al. The efficacy of transciliary flattening vitreous cavity aspiration combined with anterior chamber reconstruction in the treatment of malignant glaucoma[J]. Clin Med, 2022, 42(3): 51-52. DOI: 10.19528/j.issn.1003-3548.2022.03.019.
5. 余學清, 魏偉, 張旭. 原發性閉角型青光眼黃斑區視網膜血管密度的相關性研究[J]. 江西醫藥, 2020, 55(6): 631-635. DOI: 10.3969/j.issn.1006-2238.2020.06.001.Yu XQ, Wei W, Zhang X. Relationship of retinal blood vessel density in macular region of primary angle-closure glaucoma[J]. Jiangxi Med J, 2020, 55(6): 631-635. DOI: 10.3969/j.issn.1006-2238.2020.06.001.
6. 中華醫學會眼科學分會青光眼學組, 中國醫師協會眼科醫師分會青光眼學組. 中國青光眼指南(2020年)[J]. 中華眼科雜志, 2020, 56(8): 573-586. DOI: 10.3760/cma.j.cn112142-20200313-00182.Glaucoma Group of Ophthalmology Branch of Chinese Medical Association, Glaucoma Group of Ophthalmologist Branch of Chinese Medical Doctor Association. Guidelines for glaucoma in China (2020)[J]. Chin J Ophthalmol, 2020, 56(8): 573-586. DOI: 10.3760/cma.j.cn112142-20200313-00182.
7. 趙燦. 青光眼視野缺損分級方法[J]. 中華實驗眼科雜志, 2013, 31(3): 292-297. DOI: 10.3760/cma.j.issn.2095-0160.2013.03.020.Zhao C. Staging visual field damage in glaucoma[J]. Chin J Exp Ophthalmol, 2013, 31(3): 292-297. DOI: 10.3760/cma.j.issn.2095-0160.2013.03.020.
8. Rao HL, Dasari S, Riyazuddin M, et al. Diagnostic ability and structure-function relationship of peripapillary optical microangiography measurements in glaucoma[J]. J laucoma, 2018, 27(3): 219-226. DOI: 10.1097/IJG.0000000000000873.
9. Cao D, Yang D, Huang Z, et al. Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy[J]. Acta Diabetol, 2018, 55(5): 469-477. DOI: 10.1007/s00592-018-1115-1.
10. 胡依博, 沈策英, 張培. 光學相干斷層掃描儀檢測視網膜神經纖維層厚度在慢性原發性閉角型青光眼早期診斷中應用[J]. 山西醫藥雜志, 2021, 50(10): 1630-1632. DOI: 10.3969/j.issn.0253-9926.2021.10.014.Hu YB, Shen CY, Zhang P. Application of optical coherence tomography to detect retinal nerve fiber layer thickness in early diagnosis of chronic primary angle-closure glaucoma[J]. Shanxi Med J, 2021, 50(10): 1630-1632. DOI: 10.3969/j.issn.0253-9926.2021.10.014.
11. 王偉, 王孌, 郭瑩. 定量分析原發性急性閉角型青光眼首次發作后視盤周圍毛細血管密度參數變化[J]. 河北醫藥, 2021, 43(17): 2610-2613. DOI: 10.3969/j.issn.1002-7386.2021.17.011.Wang W, Wang L, Guo Y. Quantitative analysis of the changes of capillary density parameters around the optic disc after the first attack of primary acute angle-closure glaucoma[J]. Hebei Med J, 2021, 43(17): 2610-2613. DOI: 10.3969/j.issn.1002-7386.2021.17.011.
12. 李紅月, 惠瑜, 孫海霞, 等. 原發性開角型及慢性閉角型青光眼患者視盤毛細血管密度和視野缺損的關聯性研究[J]. 中國眼耳鼻喉科雜志, 2019, 19(6): 400-404. DOI: 10.14166/j.issn.1671-2420.2019.06.010.Li HY, Hui Y, Sun HX, et al. The relationship between optic disc capillary density and mean defect of visual field open-angle and angle-closure glaucoma[J]. Chin J Ophthalmol and Otorhinolaryngol, 2019, 19(6): 400-404. DOI: 10.14166/j.issn.1671-2420.2019.06.010.
13. Jo YH, Sung KR, Yun SC. The relationship between peripapillary vascular density and visual field sensitivity in primary open-angle and angle-closure glaucoma[J]. Invest Ophthalmol Vis Sci, 2018, 59(15): 5862-5867. DOI: 10.1167/iovs.18-25423.
14. 葉雪萍, 陳小舒, 周瑞芳. 農村地區中老年青光眼患者自我管理的現狀及其影響因素分析[J]. 廣西醫學, 2021, 43(23): 2886-2890. DOI: 10.11675/j.issn.0253-4304.2021.23.25.Ye XP, Chen XS, Zhou RF. Current situation of self-management of middle-aged and elderly glaucoma patients in rural areas and analysis of their influencing factors[J]. Guangxi Med J, 2021, 43(23): 2886-2890. DOI: 10.11675/j.issn.0253-4304.2021.23.25.
15. Bae HW, Lee N, Lee HS, et al. Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies[J/OL]. PLoS One, 2014, 9(9): e108226[2014-09-25]. https://pubmed.ncbi.nlm.nih.gov/25254373/. DOI: 10.1371/journal.pone.0108226.
16. 江方方, 邢懿, 姜波, 等. 老年女性原發性開角型青光眼的影響因素分析[J]. 實用老年醫學, 2020, 34(10): 4. DOI: 10.3969/j.issn.1003-9198.2020.10.013.Jiang FF, Xing Y, Jiang B, et al. Analysis of the influencing factors of primary open-angle glaucoma in elderly women[J]. Prac Geriat, 2020, 34(10): 4. DOI: 10.3969/j.issn.1003-9198.2020.10.013.
17. 崔淑婷, 劉成生, 劉宏. 晶體植入聯合前段玻璃體切除術對惡性青光眼患者的臨床療效及其預后影響因素分析[J]. 醫學臨床研究, 2019, 36(3): 474-476. DOI: 10.3969/j.issn.1671-7171.2019.03.020.Cui ST, Liu CS, Liu H. Clinical efficacy and prognostic factors of lens implantation combined with anterior vitrectomy for malignant glaucoma[J]. J Clin Res, 2019, 36(3): 474-476. DOI: 10.3969/j.issn.1671-7171.2019.03.020.
18. 王曉蕾, 孫興懷. 視野半側缺損的原發性開角型青光眼視網膜微循環改變的研究[J]. 中華眼科雜志, 2021, 57(3): 201-206. DOI: 10.3760/cma.j.cn112142-20201102-00734.Wang XL, Sun XH. Retinal vessel density in primary open-angle glaucoma with a hemifield defect[J]. Chin J Ophthalmol, 2021, 57(3): 201-206. DOI: 10.3760/cma.j.cn112142-20201102-00734.
19. 陳小玲, 焦亞, 賀文山, 等. 光相干斷層掃描血管成像對開角型青光眼患者視網膜血管密度和視網膜厚度的測量[J]. 中華實驗眼科雜志, 2020, 38(5): 396-401. DOI: 10.3760/cma.j.cn115989-20200326-00208.Chen XL, Jiao Y, He WS, et al. Retinal vessel density and retinal thickness as measured using optical coherence tomography angiography in open angle glaucoma[J]. Chin J Exp Ophthalmol, 2020, 38(5): 396-401. DOI: 10.3760/cma.j.cn115989-20200326-00208.
20. 盧尹悅, 黃清清, 繆曉翠. 原發性急性閉角型青光眼急性發作期視網膜血管密度特征分析[J]. 創傷與急診電子雜志, 2023, 11(1): 23-27. DOI: 10.16746/j.cnki.11-9332/r.2023.01.004.Lu YY, Huang QQ, Miao XC. Characteristics of retinal vascular density in acute primary angle-closure glaucomaduring attack phase[J]. J Trauma Emerg, 2023, 11(1): 23-27. DOI: 10.16746/j.cnki.11-9332/r.2023.01.004.

Chinese Journal of Ocular Fundus Diseases

Study on correlation of retinal blood vessel density with blood pressure and retinal thickness in the macular region of glaucoma

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