Model reconstruction and morphological observation of internal carotid artery siphon and ophthalmic artery in non-arteritic anterior ischemic optic neuropathy patients_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Jialin , Wu Lanting , Li Hongyang ,  Wang Yanling

Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;

Corresponding?author：

Wang Yanling, Email: wangyanling999@vip.sina.com

Keywords：

Optic neuropathy, ischemic; Carotid artery, internal; Ophthalmic artery; Model reconstruction; Computer tomography angiography

DOI：

10.3760/cma.j.cn511434-20210618-00326

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the morphological characteristics of internal carotid artery (ICA) siphon and ophthalmic artery (OA) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) based on CT angiography (CTA) three-dimensional reconstruction of ICA siphon and OA models. Methods A retrospective cohort study. From January 2017 to January 2019, 26 patients with 31 eyes (NAION group) who were diagnosed with NAION by ophthalmic examination at Beijing Friendship Hospital, Capital Medical Universitywere included in the study. Among them, there were 11 males with 13 eyes, and 15 females with 18 eyes; the age was 67.52±6.30 years old. Nineteen eyes of 19 non-affected contralateral eyes were selected as the contralateral eye group. Among them, there were 9 males with 9 eyes and 10 females with 10 eyes; the age was 65.95±5.66 years old. Twenty-six eyes of 26 age- and sex-matched subjects with normal fundus examination during the same period were selected as the normal control group. All subjects underwent best corrected visual acuity (BCVA), intraocular pressure, fundus photography and CTA examination. The data obtained from CT scans were reconstructed by 3D model, and the anatomical morphology of ICA siphon was divided into U-shape, V-shape, C-shape and S-shape; the diameter of ICA siphon portion and the diameter at the beginning of OA were measured. One-way analysis of variance was used to compare the diameter of the OA at the beginning of the OA and the diameter of the ICA siphon between the three groups of eyes. Results The diameters at the beginning of OA in the NAION group, the contralateral eye group, and the normal control group were 1.17±0.20, 1.34±0.17, and 1.39±0.15 mm, respectively, and the differences among the three groups were statistically significant (F=12.325, P<0.05); there was no significant difference between the contralateral eye group and the normal control group (P=0.310). In the NAION group, the anatomical morphology of the ICA siphon was U-shaped and V-shaped in 20 (64.52%) and 8 (25.81%) eyes respectively, and S and C-shaped in 3 eyes (9.67%); in the contralateral eye group, in the control group, the ICA siphon shape of the eyes examined was U-shaped and V-shaped, and S-shaped and C-shaped were rare. The diameters of the ICA siphons in the NAION group, the contralateral eye group, and the normal control group were 3.50±0.69, 3.22±0.59, and 3.55±0.54 mm, respectively. There was no significant difference between the three groups (F=1.860, P=0.163). Conclusion U-shaped and V-shaped ICA siphons are more common in NAION-affected eyes; the diameter of the starting point of OA is significantly reduced.

Citation： Wang Jialin, Wu Lanting, Li Hongyang, Wang Yanling. Model reconstruction and morphological observation of internal carotid artery siphon and ophthalmic artery in non-arteritic anterior ischemic optic neuropathy patients. Chinese Journal of Ocular Fundus Diseases, 2022, 38(7): 578-583. doi: 10.3760/cma.j.cn511434-20210618-00326 Copy

1.	Hayreh SS. Ischemic optic neuropathy[J]. Prog Retin Eye Res, 2009, 28(1): 34-62. DOI: 10.1016/j.preteyeres.2008.11.002.
2.	Kaup M, Plange N, Arend KO, et al. Retrobulbar haemodynamics in non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2006, 90: 1350-1353. DOI: 10.1136/bjo.2006.0101329.
3.	Katamay R, Fleischlin C, Gugleta K, et al. Volumetric blood flow measurement in the ophthalmic artery using colour Doppler[J]. Klin Monbl Augenheilkd, 2009, 226(4): 249-453. DOI: 10.1055/s-0028-1109304.
4.	Leffers AM, Wagner A. Neurologic complications of cerebral angiography. A retrospective study of complication rate and patient risk factors[J]. Acta Radiol, 2000, 41(3): 204-210. DOI: 10.1080/028418500127345299.
5.	Choudhry FA, Grantham JT, Rai AT, et al. Vascular geometry of the extracranial carotid arteries: an analysis of length, diameter, and tortuosity[J]. J Neurointerv Surg, 2016, 8(5): 536-540. DOI: 10.1136/neurintsurg-2015-011671.
6.	Zhong SZ, Han YJ, Yen WC. Microsurgical anatomy[M]. Boston: MTP Press, 1985.
7.	黃麗丹, 鄧麗珠, 趙文俊, 等. 頸內動脈虹吸部血流動力學模擬與影響因素[J]. 中國組織工程研究, 2015, 19(37): 5998-6004. DOI: 10.3969/j.issn.2095-4344.2015.37.018.Huang LD, Deng LZ, Zhao WJ, et al. Hemodynamics simulation of internal carotid artery siphon and relevant influential factors[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(37): 5998-6004. DOI: 10.3969/j.issn.2095-4344.2015.37.018.
8.	Jozwik K, Obidowski D. Numerical simulations of the blood flow through vertebral arteries[J]. J Biomech, 2010, 43(2): 177-185. DOI: 10.1016/j.jbiomech.2009.09.026.
9.	中華醫學會眼科學分會神經眼科學組. 我國非動脈炎性前部缺血性視神經病變診斷和治療專家共識(2015年)[J]. 中華眼科雜志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-Ophthalmology Group, Ophthalmology Branch of Chinese Medical Association. Expert consensus on the diagnosis and treatment of non-arteritic anterior ischemic optic neuropathy in my country (2015)[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
10.	Bouthillier A, van Loveren HR, Keller JT, et al. Segments of the internal carotid artery: a new classification[J]. Neurosurgery, 1996, 38(3): 425-432. DOI: 10.1097/00006123-199603000-00001.
11.	Wang H, Meng ZY, Li SG, et al. Macular evaluation of the retinal and choroidal vasculature changes in anterior ischemic optic neuropathy-a case control study[J]. BMC Ophthalmol, 2018, 18(1): 341. DOI: 10.1186/s12886-018-1007-8.
12.	劉玨君, 陳長征, 李璐, 等. 非動脈炎性前部缺血性視神經病變視盤及黃斑血流灌注變化的觀察[J]. 中華眼底病雜志, 2019, 35(3): 219-225. DOI: 10.3760/cma.j.issn.1005-1015.2019.03.002.Liu JJ, Chen CZ, Li L, et al. The blood perfusion changes of peripapillary and macular vessels in patients with nonarteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2019, 35(3): 219-225. DOI: 10.3760/cma.j.issn.1005-1015.2019.03.002.
13.	楊沫, 王偉, 魏世輝, 等. 非動脈炎性前部缺血性視神經病變光相干斷層掃描血管成像特征及其與視野的相關性分析[J]. 中華眼底病雜志, 2017, 33(5): 453-457. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.004.Yang M, Wang W, Wei SH, et al. The characteristics of optical coherence tomography angiography and its relationship with visual field defect in nonarteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 453-457. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.004.
14.	Kojima M, Irie K, Fukuda T, et al. The study of flow diversion effects on aneurysm using multiple enterprise stents and two flow diverters[J]. Asian J Neurosurg, 2012, 7: 159-165. DOI: 10.4103/1793-5482.106643.
15.	Xu B, Liu H. The three-dimensional computed tomography anatomic features of internal carotid artery-ophthalmic artery[J]. J Craniofac Surg, 2019, 30(5): 1609-1611. DOI: 10.1097/SCS.0000000000005386.
16.	Wang D, Li Z, Zheng X, et al. Head and neck CT angiography to assess the internal carotid artery stealing pathway[J]. BMC Neurology, 2020, 20(334): 1-7. DOI: 10.1186/s12883-020-01915-w.
17.	張陶然, 范世超, 張婷婷, 等. 應用CT血管造影測量眼動脈直徑的初步探討[J]. 臨床和實驗醫學雜志, 2015, 14(7): 1408-1410. DOI: 10.3969/j.issn.1671-4695.2015.017.003.Zhao TR, Fan SC, Zhang TT, et al. A preliminary study on measurement of ophthalmic artery with computed tomographic angiography[J]. Journal of Clinical and Experimental Medicine, 2015, 14(7): 1408-1410. DOI: 10.3969/j.issn.1671-4695.2015.017.003.
18.	Lopes D, Puga H, Teixeira J, et al. Blood flow simulations in patient-specific geometries of the carotid artery: a systematic review[J/OL]. J Biomech, 2020, 111: 110019[2020-10-09]. https://pubmed.ncbi.nlm.nih.gov/32905972/. DOI: 10.1016/j.jbiomech.2020.110019.
19.	Zhou H, Meng L, Zhou W, et al. Computational and experimental assessment of infuences of hemodynamic shear stress on carotid plaque[J]. BioMed Eng OnLine, 2017, 16(1): 92. DOI: 10.1186/s12938-017-0386-z.
20.	Sarrami-Foroushani A, Nasr Esfahany M, Nasiraei Moghaddam A, et al. Velocity measurement in carotid artery: quantitative comparison of time-resolved 3D phase-contrast MRI and image-based computational fluid dynamics[J/OL]. Iran J Radiol, 2015, 12(4): e18286[2015-10-17]. https://pubmed.ncbi.nlm.nih.gov/26793288/. DOI: 10.5812/iranjradiol.18286.
21.	Chrzanowski R. The assessment of the intracranial part of the internal carotidartery[J]. Neuroradiology, 1971, 2(4): 223-226. DOI: 10.1007/BF00337571.
22.	孫學進, 龐瑞麟. 頸內動脈虹吸部應用解剖與數字減影血管造影對照研究及應用[J]. 介入放射學雜志, 2004, 13(1): 66-67. DOI: 10.3969/j.issn.1008-794X.2004.01.021.Sun XJ, Long RL. The correlation study of the applied anatomy of internal carotid artery with brain DSA[J]. J Interventional Radiology, 2004, 13(1): 66-67. DOI: 10.3969/j.issn.1008-794X.2004.01.021.

1. Hayreh SS. Ischemic optic neuropathy[J]. Prog Retin Eye Res, 2009, 28(1): 34-62. DOI: 10.1016/j.preteyeres.2008.11.002.
2. Kaup M, Plange N, Arend KO, et al. Retrobulbar haemodynamics in non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2006, 90: 1350-1353. DOI: 10.1136/bjo.2006.0101329.
3. Katamay R, Fleischlin C, Gugleta K, et al. Volumetric blood flow measurement in the ophthalmic artery using colour Doppler[J]. Klin Monbl Augenheilkd, 2009, 226(4): 249-453. DOI: 10.1055/s-0028-1109304.
4. Leffers AM, Wagner A. Neurologic complications of cerebral angiography. A retrospective study of complication rate and patient risk factors[J]. Acta Radiol, 2000, 41(3): 204-210. DOI: 10.1080/028418500127345299.
5. Choudhry FA, Grantham JT, Rai AT, et al. Vascular geometry of the extracranial carotid arteries: an analysis of length, diameter, and tortuosity[J]. J Neurointerv Surg, 2016, 8(5): 536-540. DOI: 10.1136/neurintsurg-2015-011671.
6. Zhong SZ, Han YJ, Yen WC. Microsurgical anatomy[M]. Boston: MTP Press, 1985.
7. 黃麗丹, 鄧麗珠, 趙文俊, 等. 頸內動脈虹吸部血流動力學模擬與影響因素[J]. 中國組織工程研究, 2015, 19(37): 5998-6004. DOI: 10.3969/j.issn.2095-4344.2015.37.018.Huang LD, Deng LZ, Zhao WJ, et al. Hemodynamics simulation of internal carotid artery siphon and relevant influential factors[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(37): 5998-6004. DOI: 10.3969/j.issn.2095-4344.2015.37.018.
8. Jozwik K, Obidowski D. Numerical simulations of the blood flow through vertebral arteries[J]. J Biomech, 2010, 43(2): 177-185. DOI: 10.1016/j.jbiomech.2009.09.026.
9. 中華醫學會眼科學分會神經眼科學組. 我國非動脈炎性前部缺血性視神經病變診斷和治療專家共識(2015年)[J]. 中華眼科雜志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-Ophthalmology Group, Ophthalmology Branch of Chinese Medical Association. Expert consensus on the diagnosis and treatment of non-arteritic anterior ischemic optic neuropathy in my country (2015)[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
10. Bouthillier A, van Loveren HR, Keller JT, et al. Segments of the internal carotid artery: a new classification[J]. Neurosurgery, 1996, 38(3): 425-432. DOI: 10.1097/00006123-199603000-00001.
11. Wang H, Meng ZY, Li SG, et al. Macular evaluation of the retinal and choroidal vasculature changes in anterior ischemic optic neuropathy-a case control study[J]. BMC Ophthalmol, 2018, 18(1): 341. DOI: 10.1186/s12886-018-1007-8.
12. 劉玨君, 陳長征, 李璐, 等. 非動脈炎性前部缺血性視神經病變視盤及黃斑血流灌注變化的觀察[J]. 中華眼底病雜志, 2019, 35(3): 219-225. DOI: 10.3760/cma.j.issn.1005-1015.2019.03.002.Liu JJ, Chen CZ, Li L, et al. The blood perfusion changes of peripapillary and macular vessels in patients with nonarteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2019, 35(3): 219-225. DOI: 10.3760/cma.j.issn.1005-1015.2019.03.002.
13. 楊沫, 王偉, 魏世輝, 等. 非動脈炎性前部缺血性視神經病變光相干斷層掃描血管成像特征及其與視野的相關性分析[J]. 中華眼底病雜志, 2017, 33(5): 453-457. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.004.Yang M, Wang W, Wei SH, et al. The characteristics of optical coherence tomography angiography and its relationship with visual field defect in nonarteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 453-457. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.004.
14. Kojima M, Irie K, Fukuda T, et al. The study of flow diversion effects on aneurysm using multiple enterprise stents and two flow diverters[J]. Asian J Neurosurg, 2012, 7: 159-165. DOI: 10.4103/1793-5482.106643.
15. Xu B, Liu H. The three-dimensional computed tomography anatomic features of internal carotid artery-ophthalmic artery[J]. J Craniofac Surg, 2019, 30(5): 1609-1611. DOI: 10.1097/SCS.0000000000005386.
16. Wang D, Li Z, Zheng X, et al. Head and neck CT angiography to assess the internal carotid artery stealing pathway[J]. BMC Neurology, 2020, 20(334): 1-7. DOI: 10.1186/s12883-020-01915-w.
17. 張陶然, 范世超, 張婷婷, 等. 應用CT血管造影測量眼動脈直徑的初步探討[J]. 臨床和實驗醫學雜志, 2015, 14(7): 1408-1410. DOI: 10.3969/j.issn.1671-4695.2015.017.003.Zhao TR, Fan SC, Zhang TT, et al. A preliminary study on measurement of ophthalmic artery with computed tomographic angiography[J]. Journal of Clinical and Experimental Medicine, 2015, 14(7): 1408-1410. DOI: 10.3969/j.issn.1671-4695.2015.017.003.
18. Lopes D, Puga H, Teixeira J, et al. Blood flow simulations in patient-specific geometries of the carotid artery: a systematic review[J/OL]. J Biomech, 2020, 111: 110019[2020-10-09]. https://pubmed.ncbi.nlm.nih.gov/32905972/. DOI: 10.1016/j.jbiomech.2020.110019.
19. Zhou H, Meng L, Zhou W, et al. Computational and experimental assessment of infuences of hemodynamic shear stress on carotid plaque[J]. BioMed Eng OnLine, 2017, 16(1): 92. DOI: 10.1186/s12938-017-0386-z.
20. Sarrami-Foroushani A, Nasr Esfahany M, Nasiraei Moghaddam A, et al. Velocity measurement in carotid artery: quantitative comparison of time-resolved 3D phase-contrast MRI and image-based computational fluid dynamics[J/OL]. Iran J Radiol, 2015, 12(4): e18286[2015-10-17]. https://pubmed.ncbi.nlm.nih.gov/26793288/. DOI: 10.5812/iranjradiol.18286.
21. Chrzanowski R. The assessment of the intracranial part of the internal carotidartery[J]. Neuroradiology, 1971, 2(4): 223-226. DOI: 10.1007/BF00337571.
22. 孫學進, 龐瑞麟. 頸內動脈虹吸部應用解剖與數字減影血管造影對照研究及應用[J]. 介入放射學雜志, 2004, 13(1): 66-67. DOI: 10.3969/j.issn.1008-794X.2004.01.021.Sun XJ, Long RL. The correlation study of the applied anatomy of internal carotid artery with brain DSA[J]. J Interventional Radiology, 2004, 13(1): 66-67. DOI: 10.3969/j.issn.1008-794X.2004.01.021.

Previous Article
Clinical features of infant cytomegalovirus infection
Next Article
Long-term effectiveness and safety of new channelrhodopsin PsCatCh2.0 in the treatment of retinal degenerative diseases

Chinese Journal of Ocular Fundus Diseases

Model reconstruction and morphological observation of internal carotid artery siphon and ophthalmic artery in non-arteritic anterior ischemic optic neuropathy patients

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content