Observation on the imaging characteristics of optical coherence tomography angiography in eyes with macular telangiectasia type 2_Chinese Journal of Ocular Fundus Diseases

Authors：

Yang Tingting , Zhao Yue ,  Yao Jin

Nanjing Medical University Eye Hospital, Nanjing 210029, China;

Corresponding?author：

Yao Jin, Email: dryaojin@126.com

Keywords：

Retinal telangiectasis; Tomography, optical coherence; Regional blood flow

DOI：

10.3760/cma.j.cn511434-20210425-00203

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the imaging characteristics of optical coherence tomography angiography in macular telangiectasia type 2 (Mac-Tel 2). Methods A retrospective case analysis. From October 2017 to June 2021, 11 patients (22 eyes) diagnosed as Mac-Tel type 2 by multi-modal imaging in Nanjing Medical University Eye Hospital were included in this study. There were 5 males (10 eyes) and 6 females (12 eyes). The age were 41.61±11.32 years old. All patients underwent the examinations of best corrected visual acuity, indirect ophthalmoscope, fundus color photography, fluorescein fundus angiography (FFA), optical coherence tomography (OCT), and OCT angiography (OCTA). The scope of 3 mm × 3 mm in macular area of eyes was scanned by OCTA. After automatic image processing, the system could provide the blood flow image of capillary layer, deep capillary layer, outer retina, choroidal capillary layer, and the B-scan image. The imaging characteristics were observed. Results Among the 22 eyes, 14 eyes were in the early stage of the disease, and 8 eyes had secondary subretinal neovascularization (SRN) and/or choroidal neovascularization (CNV). FFA examination that in the early stage of the disease, the capillaries near the fovea were dilated, the blood vessels were stretched, and the late fluorescence was mainly stained; high-fluorescence leakage was seen when SRN and CNV were developed. OCTA examination showed that in the early stage of the disease, the temporal capillaries in the macular area were dilated and stretched, especially in the deep layer. The capillary space was enlarged, and the right-angled venules were seen to change and infiltrate into the deep layer; when the lesions invaded the outer retina, flower clusters-like SRN were seen; neovascularization was seen in the outer retina and choroidal capillary layer when CNV was developed. B-scan image showed that in the early stage of the disease, irregular weak reflex cavities and lamellar holes change between the neuroepithelial layers; secondary SRN and CNV showed strong little clumpy reflexes accompanied by abundant blood flow signals. Conclusion The image characteristics of OCTA in the eyes of Mac-Tel 2 were dilated, stretched superficial and deep temporal capillaries in the macula area and right-angled changes in blood vessels.

Citation： Yang Tingting, Zhao Yue, Yao Jin. Observation on the imaging characteristics of optical coherence tomography angiography in eyes with macular telangiectasia type 2. Chinese Journal of Ocular Fundus Diseases, 2021, 37(12): 937-941. doi: 10.3760/cma.j.cn511434-20210425-00203 Copy

1.	Davidorf FH, Pressman MD, Chambers RB. Juxtafoveal telangiectasis-a name change?[J]. Retina, 2004, 24(3): 474-478. DOI: 10.1097/00006982-200406000-00028.
2.	Gass JD, Oyakawa RT. Idiopathic juxtafoveolar retinal telangiectasis[J]. Arch Ophthalmol, 1982, 100(5): 769-780. DOI: 10.1001/archopht.1982.01030030773010.
3.	Gass JD, Blodj BA. Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study[J]. Ophthalmology, 1993, 100(10): 1536-1546. DOI: 10.1016/S0161-6420(93)31447-8.
4.	Yannuzzi LA, Bardal AM, Frund KB, et al. Idiopathic macular telangietasia[J]. Arch Ophthalmol, 2006, 124(4): 450-460. DOI: 10.1001/archopht.124.4.450.
5.	Spaide RF, Klancnik JM, Cooney MJ. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography[J]. JAMA Ophthalmol, 2015, 133(1): 66-73. DOI: 10.1001/jamaophthalmol.2014.3950.
6.	Chidambara L, Gadde SG, Yadav NK, et al. Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography[J]. Br J Ophthalmol, 2016, 100(11): 1482-1488. DOI: 10.1136/bjophthalmol-2015-307941.
7.	吉宇瑩, 張雄澤, 李妙玲, 等. 2型黃斑毛細血管擴張癥眼底及影像特征觀察[J]. 中華眼底病雜志, 2016, 32(4): 382-386. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.009.Ji YY, Zhang XZ, Li ML, et al. Characteristics of fundus image in macular telangiectasia type 2[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 382-386. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.009.
8.	才藝, 石璇, 趙明威, 等. 特發性黃斑視網膜血管擴張癥2型的臨床特點及診斷治療研究進展[J]. 中華眼科雜志, 2019, 55(1): 68-72. DOI: 10.3760/cma.j.issn.0412-4081.2019.01.017.Cai Y, Shi X, Zhao MW, et al. Characteristics, multimodality imaging and treatment of macular telangiectasia type 2[J]. Chin J Ocul Fundus Dis, 2019, 55(1): 68-72. DOI: 10.3760/cma.j.issn.0412-4081.2019.01.017.
9.	Charbel Issa P, Gillies MC, Chew EY, et al. Macular telangiectasia type 2[J]. Prog Retin Eye Res, 2013, 34: 49-77. DOI: 10.1016/j.preteyeres.2012.11.002.
10.	Gillies MC, Zhu M, Chew E, et al. Familial asymptomatic macular telangiectasia type 2[J]. Ophthalmology, 2009, 116(12): 2422-2429. DOI: 10.1016/j.ophtha.2009.05.010.
11.	胡立影, 李志清, 于榮國, 等. 特發性黃斑毛細血管擴張癥的研究現狀與進展[J]. 中華眼底病雜志, 2016, 32(4): 440-444. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.026.Hu LY, Li ZQ, Yu RG, et al. The status and progress of studies of idiopathic parafoveal telangiectasis[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 440-444. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.026.
12.	毛蕾, 宮媛媛. 特發性旁中心凹毛細血管擴張癥診治進展[J]. 中華眼視光學與視覺科學雜志, 2016, 18(6): 377-380. DOI: 10.3760/cma.j.issn.1674-845X.2016.06.012.Mao L, Gong YY. The development of the diagnosis and treatment of parafoveal telangiectasis[J]. Chin J Optom Ophthalmol Vis Sci, 2016, 18(6): 377-380. DOI: 10.3760/cma.j.issn.1674-845X.2016.06.012.
13.	Spaide RF, Klancnik JM, Cooney MJ, et al. Volume-rendering optical coherence tomography angiography of macular telangiectasia type 2[J]. Ophthalmology, 2015, 122(11): 2261-2269. DOI: 10.1016/j.ophtha.2015.07.025.
14.	劉乘熙, 丁小燕. 2型黃斑毛細血管擴張癥研究進展[J]. 中華實驗眼科雜志, 2018, 36(8): 653-656. DOI: 10.3760/cma.j.issn.1005-1015.2018.08.016.Liu CX, Ding XY. The research progress of macular telangiectasia type 2[J]. Chin J Exp Ophthalmol, 2018, 36(8): 653-656. DOI: 10.3760/cma.j.issn.1005-1015.2018.08.016.

1. Davidorf FH, Pressman MD, Chambers RB. Juxtafoveal telangiectasis-a name change?[J]. Retina, 2004, 24(3): 474-478. DOI: 10.1097/00006982-200406000-00028.
2. Gass JD, Oyakawa RT. Idiopathic juxtafoveolar retinal telangiectasis[J]. Arch Ophthalmol, 1982, 100(5): 769-780. DOI: 10.1001/archopht.1982.01030030773010.
3. Gass JD, Blodj BA. Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study[J]. Ophthalmology, 1993, 100(10): 1536-1546. DOI: 10.1016/S0161-6420(93)31447-8.
4. Yannuzzi LA, Bardal AM, Frund KB, et al. Idiopathic macular telangietasia[J]. Arch Ophthalmol, 2006, 124(4): 450-460. DOI: 10.1001/archopht.124.4.450.
5. Spaide RF, Klancnik JM, Cooney MJ. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography[J]. JAMA Ophthalmol, 2015, 133(1): 66-73. DOI: 10.1001/jamaophthalmol.2014.3950.
6. Chidambara L, Gadde SG, Yadav NK, et al. Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography[J]. Br J Ophthalmol, 2016, 100(11): 1482-1488. DOI: 10.1136/bjophthalmol-2015-307941.
7. 吉宇瑩, 張雄澤, 李妙玲, 等. 2型黃斑毛細血管擴張癥眼底及影像特征觀察[J]. 中華眼底病雜志, 2016, 32(4): 382-386. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.009.Ji YY, Zhang XZ, Li ML, et al. Characteristics of fundus image in macular telangiectasia type 2[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 382-386. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.009.
8. 才藝, 石璇, 趙明威, 等. 特發性黃斑視網膜血管擴張癥2型的臨床特點及診斷治療研究進展[J]. 中華眼科雜志, 2019, 55(1): 68-72. DOI: 10.3760/cma.j.issn.0412-4081.2019.01.017.Cai Y, Shi X, Zhao MW, et al. Characteristics, multimodality imaging and treatment of macular telangiectasia type 2[J]. Chin J Ocul Fundus Dis, 2019, 55(1): 68-72. DOI: 10.3760/cma.j.issn.0412-4081.2019.01.017.
9. Charbel Issa P, Gillies MC, Chew EY, et al. Macular telangiectasia type 2[J]. Prog Retin Eye Res, 2013, 34: 49-77. DOI: 10.1016/j.preteyeres.2012.11.002.
10. Gillies MC, Zhu M, Chew E, et al. Familial asymptomatic macular telangiectasia type 2[J]. Ophthalmology, 2009, 116(12): 2422-2429. DOI: 10.1016/j.ophtha.2009.05.010.
11. 胡立影, 李志清, 于榮國, 等. 特發性黃斑毛細血管擴張癥的研究現狀與進展[J]. 中華眼底病雜志, 2016, 32(4): 440-444. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.026.Hu LY, Li ZQ, Yu RG, et al. The status and progress of studies of idiopathic parafoveal telangiectasis[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 440-444. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.026.
12. 毛蕾, 宮媛媛. 特發性旁中心凹毛細血管擴張癥診治進展[J]. 中華眼視光學與視覺科學雜志, 2016, 18(6): 377-380. DOI: 10.3760/cma.j.issn.1674-845X.2016.06.012.Mao L, Gong YY. The development of the diagnosis and treatment of parafoveal telangiectasis[J]. Chin J Optom Ophthalmol Vis Sci, 2016, 18(6): 377-380. DOI: 10.3760/cma.j.issn.1674-845X.2016.06.012.
13. Spaide RF, Klancnik JM, Cooney MJ, et al. Volume-rendering optical coherence tomography angiography of macular telangiectasia type 2[J]. Ophthalmology, 2015, 122(11): 2261-2269. DOI: 10.1016/j.ophtha.2015.07.025.
14. 劉乘熙, 丁小燕. 2型黃斑毛細血管擴張癥研究進展[J]. 中華實驗眼科雜志, 2018, 36(8): 653-656. DOI: 10.3760/cma.j.issn.1005-1015.2018.08.016.Liu CX, Ding XY. The research progress of macular telangiectasia type 2[J]. Chin J Exp Ophthalmol, 2018, 36(8): 653-656. DOI: 10.3760/cma.j.issn.1005-1015.2018.08.016.

Chinese Journal of Ocular Fundus Diseases

Observation on the imaging characteristics of optical coherence tomography angiography in eyes with macular telangiectasia type 2

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content