Assessment of choroidal vascularity index in healthy eyes of different subfoveal choroidal areas on enhanced depth imaging optical coherence tomography_Chinese Journal of Ocular Fundus Diseases

Authors：

Guo Qihan ¹ , Li Shuang ² ,  Wang Kang ²

1. School of Clinical Medicine, Capital Medial University, Beijing 100069, China;
2. Department of Ophtalmology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China;

Corresponding?author：

Wang Kang, Email: bmbn2000@163.com

Keywords：

Tomography, optical coherence; Healthy eyes; Choroidal vascularity index

DOI：

10.3760/cma.j.cn511434-20190903-00278

Video：

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Objective To observe the effect of spectral-domain OCT with different subfoveal choroidal areas on choroid vascular index (CVI) in normal healthy eyes.Methods Retrospective clinical study. From October 2017 to May 2018, 174 eyes of 87 healthy people who visited in the Ophthalmology Department of Beijing Friendship Hospital and had no eye abnormalities were included in the study. All patients received single line scan of macular fovea by enhanced depth imaging OCT. After binary processing of the collected choroidal images, CVI as the center radius of 750, 1500, 3000 and 4500 μm were calculated. Repeated measurement analysis of variance was performed for comparison of CVI between groups.Results The mean values of CVI in the 750, 1500, 3000 and 4500 μm groups were 0.681±0.003, 0.678±0.002, 0.677±0.002 and 0.676±0.002, respectively. The difference between the 750 μm group and the 4500 μm group was 0.005±0.002 (P=0.009). The other pairwise comparison results showed no statistically significant difference (P＞0.05).Conclusion The CVI is different in healthy eyes with the different distance from macular fovea.

Citation： Guo Qihan, Li Shuang, Wang Kang. Assessment of choroidal vascularity index in healthy eyes of different subfoveal choroidal areas on enhanced depth imaging optical coherence tomography. Chinese Journal of Ocular Fundus Diseases, 2020, 36(5): 366-369. doi: 10.3760/cma.j.cn511434-20190903-00278 Copy

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11.	Wang NK, Lai CC, Chu HY, et al. Classification of early dry-type myopic maculopathy with macular choroidal thickness[J]. Am J Ophthalmol, 2012, 153(4): 669-677. DOI: 10.1016/j.ajo.2011.08.039.
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14.	Campos A, Campos EJ, Martins J, et al. Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema[J]. Acta Ophthalmol, 2017, 95(5): 446-459. DOI: 10.1111/aos.13210.
15.	Wallman J, Nickla DL. The multifunctional choroid[J]. Prog Retin Eye Res, 2010, 29(2): 144-168. DOI: 10.1016/j.preteyeres.2009.12.002.
16.	韓鵬飛, 倪宇馨, 李雙農. 糖尿病脈絡膜病變的臨床研究進展[J]. 中國中醫眼科雜志, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.Han PF, Ni YX, Li SN. Clinical research advances of diabetic choroidopathy[J]. Chinese Journal of Chinese Ophthalmology, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.
17.	Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis[J]. Nat Methods, 2012, 9(7): 676-682. DOI: 10.1038/nmeth.2019.
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1. Alm A, Bill A. Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues[J]. Exp Eye Res, 1973, 15(1): 15-29. DOI: 10.1016/0014-4835(73)90185-1.
2. Wei X, Sonoda S, Mishra C, et al. Comparison of choroidal vascularity markers on optical coherence tomography using two-image binarization techniques[J]. Invest Ophthalmol Vis Sci, 2018, 59(3): 1206-1211. DOI: 10.1167/iovs.17-22720.
3. 王薇, 李爽, 李紅陽, 等. 急性中心性漿液性脈絡膜視網膜病變患者脈絡膜血管指數及中心凹下脈絡膜厚度測量分析[J]. 中華眼底病雜志, 2019, 35(4): 353-357. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.008.Wang W, Li S, Li HY, et al. Measurement and analysis of choroidal vascularity index and subfoveal choroidal thickness in central serous chorioretinopathy[J]. Chin J Ocul Fundus Dis, 2019, 35(4): 353-357. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.008.
4. 孫曉麗, 叢春霞, 李立, 等. 光相干斷層掃描血管成像與傳統多模式眼底成像對滲出型老年性黃斑變性脈絡膜新生血管診斷與活動性判斷的對比觀察[J]. 中華眼底病雜志, 2017, 33(1): 10-14. DOI: 10.3760/cma.j.issn.1005-1015.2017.01.0044.Sun XL, Cong CX, Li L, et al. Optical coherence tomography angiography and traditional multimodal fundus imaging in the diagnosis and activity evaluation of choroidal neovascularization in exudative age-related macular degeneration[J]. Chin J Ocul Fundus Dis, 2017, 33(1): 10-14. DOI: 10.3760/cma.j.issn.1005-1015.2017.01.0044.
5. 郎需強, 王康, 李爽, 等. 脈絡膜血管指數在視網膜中央靜脈阻塞治療預后評估中價值初步分析[J]. 臨床眼科雜志, 2019, 27(4): 298-303. DOI: 10.3969/j.issn.1006-8422.Lang XQ, Wang K, Li S, et al. A pilot study of choroidal vascularity index as a predictor for treatment outcomes in central retinal vein occlu-sion[J]. J Clin Ophthalmol, 2019, 27(4): 298-303. DOI: 10.3969/j.issn.1006-8422.
6. Agrawal R, Gupta P, Tan KA, et al. Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study[J/OL]. Sci Rep, 2016, 6: 21090[2016-02-12]. https://www.nature.com/articles/srep21090. DOI: 10.1038/srep21090.
7. Hayreh SS. Posterior ciliary artery circulation in health and disease: the Weisenfeld lecture[J]. Invest Ophthalmol Vis Sci, 2004, 45(3): 749-757. DOI: 10.1167/iovs.03-0469.
8. Sonoda S, Sakamoto T, Yamashita T, et al. Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images[J]. Am J Ophthalmol, 2015, 159(6): 1123-1131. DOI: 10.1016/j.ajo.2015.03.005.
9. 劉然, 晏穎, 陳曉. 頸內動脈狹窄患者的脈絡膜厚度和脈管指數的改變[J]. 國際眼科雜志, 2020, 20(3): 533-536. DOI: 10.3980/j.issn.1672-5123.Liu R, Yan Y, Chen X. Changes of choroidal thickness and vascular index in patients with internal carotid artery stenosis[J]. Int Eye Sci, 2020, 20(3): 533-536. DOI: 10.3980/j.issn.1672-5123.
10. Agrawal R, Wei X, Goud A, et al. Influence of scanning area on choroidal vascularity index measurement using optical coherence tomography[J]. Acta Ophthalmol, 2017, 95(8): 770-775. DOI: 10.1111/aos.13442.
11. Wang NK, Lai CC, Chu HY, et al. Classification of early dry-type myopic maculopathy with macular choroidal thickness[J]. Am J Ophthalmol, 2012, 153(4): 669-677. DOI: 10.1016/j.ajo.2011.08.039.
12. Tan CS, Ngo WK, Cheong KX. Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes[J]. Br J Ophthalmol, 2015, 99(3): 354-358. DOI: 10.1136/bjo.79.1.1.
13. Unsal E, Eltutar K, Zirtilo?lu S, et al. Choroidal thickness in patients with diabetic retinopathy[J]. Clin Ophthalmol, 2014, 8: 637-642. DOI: 10.2147/OPTH.S59395.
14. Campos A, Campos EJ, Martins J, et al. Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema[J]. Acta Ophthalmol, 2017, 95(5): 446-459. DOI: 10.1111/aos.13210.
15. Wallman J, Nickla DL. The multifunctional choroid[J]. Prog Retin Eye Res, 2010, 29(2): 144-168. DOI: 10.1016/j.preteyeres.2009.12.002.
16. 韓鵬飛, 倪宇馨, 李雙農. 糖尿病脈絡膜病變的臨床研究進展[J]. 中國中醫眼科雜志, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.Han PF, Ni YX, Li SN. Clinical research advances of diabetic choroidopathy[J]. Chinese Journal of Chinese Ophthalmology, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.
17. Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis[J]. Nat Methods, 2012, 9(7): 676-682. DOI: 10.1038/nmeth.2019.
18. Xin W, Shozo S, Chitaranjan M, et al. Comparison of choroidal vascularity markers on optical coherence tomography using two-image binarization techniques[J]. Invest Opthalmol Vis Sci, 2018, 59(3): 1206-1211. DOI: 10.1038/eye.2013.78.

Chinese Journal of Ocular Fundus Diseases

Assessment of choroidal vascularity index in healthy eyes of different subfoveal choroidal areas on enhanced depth imaging optical coherence tomography

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